Granulocyte-Macrophage Colony-Stimulating Factor

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

Also Known As:

GM-CSF; CSF-2; Colony Stimulating Factor, Granulocyte Macrophage; TC-GM-CSF; Tumor-Cell Human GM Colony-Stimulating Factor; Cell-Stimulating Factor, Histamine-Producing; Granulocyte Macrophage Colony Stimulating Factor; Histamine Producing Cell Stimulating Factor; Tumor Cell Human GM Colony Stimulating Factor; CSF-GM; Colony-Stimulating Factor, Granulocyte-Macrophage; Histamine-Producing Cell-Stimulating Factor; Colony-stimulating factor 2

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Granulocyte-Macrophage Colony-Stimulating Factor: 8112
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Granulocyte-Macrophage Colony-Stimulating Factor: 8112
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Hematopoietic Cell Growth Factors: 13
      - Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112

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Disease

Drug/Important Bio-Agent (IBA)